Association of lower Th2 cytokines with CAL in Kawasaki disease (Ho-Chang Kuo, MD, PhD)郭和昌醫師川崎正研究

Association of lower eosinophil-related T helper 2 (Th2) cytokines with coronary artery lesions in Kawasaki disease.

Kawasaki disease (KD) is a systemic febrile vasculitis particular coronary

artery involvement. Eosinophilia has been found in our and other

studies in KD. This study further investigates whether eosinophilrelated

T helper 2 (Th2) cytokines or the activation marker (eosinophil

cationic protein – ECP) is involved in KD with coronary artery lesions

( CAL ). A total of 95 KD patients were enrolled for this study. Plasma

samples were subjected to the measurement of interleukin (IL)-4, IL-5,

and eotaxin by Luminex-Bedalyte multiplex beadmates system and to

the measurement of ECP by fluoroimmunoassay. Patients with KD had

higher eosinophils than controls. Eosinophil-related mediators: IL-4,

IL-5, eotaxin, and ECP levels were also higher in KD patients than

controls before intravenous immunoglobulin (IVIG) treatment. After

IVIG treatment, ECP decreased but IL-4, IL-5, and eotaxin increased

significantly. The higher the IL-5 and eosinophil levels after IVIG

treatment, the lower rate of CAL was found. Changes of eosinophils

after IVIG treatment were positively correlated to changes of IL-5 levels

but not ECP levels. An increase of eosinophils and IL-5, but not ECP

levels after IVIG treatment, was inversely correlated with CAL formation

in KD.



嗜伊紅性白血球的動態變化及與免疫球蛋白治療反應之間的關聯，因此我們進一步研究與嗜伊紅性白血球有關之免疫陰性相關之細胞激素及嗜伊紅性白血球之相關活化因子(ECP)與川崎症的相關性及與嗜伊紅性血球的變化關係。